The BEAF-32 insulator coordinates genome organization and function during the evolution of Drosophila species

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Figure 6.
Figure 6.

Simplified models for the role of BEAF-32 during evolution of Drosophila species. (A) Two alternative possibilities explaining how alterations in BEAF-32 binding may affect transcription. Blocks indicate genes. (Black and white) Different transcription regulatory modes of the genes. (Gray) Converged regulation for the two genes. Gain or loss of BEAF-32 binding when gene pairs are reorganized to maintain proper transcription (top). Gain or loss of BEAF-32 binding when gene organization does not change to create transcription diversity (bottom). (B) Phylogeny and phenotype of Drosophila species analyzed in this study.

This Article

  1. Genome Res. 22: 2199-2207

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