Figure 7.
Diagram comparing independent dCTCF sites and dCTCF sites aligned with BEAF-32 and SU(HW). dCTCF, BEAF-32, and SU(HW) function similarly through the recruitment of CP190 and MOD(MDG4). Aligned dCTCF sites are enriched for the secondary DNA sequence and CP190. Ultimately, alignment may allow for cooperative recruitment of CP190 and MOD(MDG4), ensuring that dCTCF establishes a functional insulator complex at domain borders. Recruitment of additional proteins, such as L(3)MBT and Chromator, may also contribute to insulator activities at these loci.
