Figure 1.
(A) Genome-wide occupancy of cohesin, CTCF, tissue-specific and ubiquitous TFs in primary mouse liver as measured by ChIP-seq and shown near the Pck1 gene. Cohesin colocalizes with CTCF as well as with clusters of transcription factors in the absence of CTCF, one of which can be seen overlapping the TSS of the Pck1 gene. (B) Venn diagram showing CTCF and cohesin (RAD21, STAG1, STAG2) occurrence within CRMs. The pie charts indicate genomic locations of all CRMs (background), as well as those containing CTCF and CNC. The latter occur within promoter regions at a higher relative frequency compared with the other two classes.
