Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 6.
Figure 6.

GEN and BPA induce ESR1 binding and expression changes in T-47D. (A) The overlap between E2-induced ESR1 binding sites in ECC-1 and T-47D is displayed. (B) Binding site signal strength is plotted for each binding site with E2-induced signal strength (replicate 1) on the x-axis vs. E2 (black; replicate 2), GEN (green; replicate 1), and BPA (red; replicate 1) signal strength on the y-axis for T-47D. (C) The overlap between genes regulated by E2, GEN, or BPA is shown as a Venn diagram. (D) The number of genes in each group that are within 50 kb of ESR1 binding sites (also broken out by group) is shown for up-regulated genes.

This Article

  1. Published in Advance September 26, 2012, doi: 10.1101/gr.135681.111 Genome Res. 22: 2153-2162

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research