Figure 2.
Properties of E2-, GEN-, and BPA-induced ESR1 binding sites. (A) The proportion of genomic locations of ESR1 binding sites with respect to genes is displayed. The genomic background is also shown. (B) The most prevalent sequence motif found in ESR1 binding sites found after E2-, GEN-, or BPA-treatment matches the canonical estrogen response element (ERE). (C) Distributions of ERE motif strength, measured as log relative affinity compared to highest possible affinity site, are shown as boxplots. Boxes cover 25th to 75th percentiles, and the whiskers define the 95% confidence interval.
