(A) Genome-wide profiles of DNAm and gene expression. The x-axis represents the genomic location with chromosomes represented as rows. The y-axis represents the significance of the differences between UC patients and healthy individuals and is displayed as –log(p) for the mRNA and as log(p) for the epigenetic modifications. Effect size (induction/fold change) is encoded by colors. Methylation: (black) up-regulated, (blue) not regulated, (purple) down-regulated; mRNA-expression: (red) up-regulated, (yellow) no regulation, (green) down-regulated. (B) Higher resolution map for selected candidate locus HKDC1 (display and color coding according to Fig. 1A; the dotted line indicates the significance threshold). A higher resolution of this map is provided in Supplemental Figure S1A–X.
