The transcriptional landscape and mutational profile of 87 lung adenocarcinomas. Each column characterizes the signature of cancer in one patient. Patients are classified into smokers and never-smokers. Each row represents a selected gene of interest, including known driver genes of lung adenocarcinoma, genes observed to be frequently mutated (≥3 cancers), and protein kinase genes involved in fusion and exon-skipping (ES) events. Cells are colored to indicate discovery of somatic mutations (red), gene overexpression (blue), both (purple), and fusion and ES events (green) in cancer tissue. Patients with lymph node metastasis are indicated with “M” on the bottom row.
