Figure 6.
Kidney cancer gene pathways. Kidney cancer is fundamentally a metabolic disease. Each of the kidney cancer genes, VHL, MET, FLCN, FH, SDH, TSC1, TSC2, and TFE3 affects the cell's ability to sense oxygen, iron, nutrients, and most particularly in the Krebs cycle enzymes, FH and SDH, and energy. Further genomics studies elucidating these kidney cancer gene pathways will provide the foundation for the development of targeted approaches for therapy for these diseases. (Fig. 6 adapted from Linehan et al. 2010.)
