Figure 3.
Type 1 papillary kidney cancer. Hereditary papillary renal carcinoma (HPRC) is an autosomal dominant hereditary cancer syndrome (D) in which affected individuals are at risk for the development of bilateral kidney cancer (A,B) that is type 1 papillary histologic type (C). Patients affected with HPRC are characterized by germline mutation of the MET gene. MET mutations are also found in a subset of tumors (13%) from patients with sporadic, nonhereditary papillary kidney cancer. (Fig. 3 from Linehan et al. 2003.)
