Figure 5.
Modeling of HD variants. (A) Co-crystal structure of Engrailed bound to TAATTA (Fraenkel et al. 1998). (B) Model of HD variant STRER bound to its cognate site taaCGG. (C) Model of HD variant LAKDQ bound to its cognate site taaGGA. (D) Model of HD variant RSNQK bound to its cognate site taaCCA. (Dotted lines) Interactions between the protein and DNA (either hydrogen bonds or van der Waals interactions), where the numerical values indicate the distance in angstroms.
