Figure 6.
Early replication domains are characterized by high origin density. (A) Shown is the origin density in the three mouse cell lines calculated using a 100-kb sliding window along the chromosomal region. The computed gene and CGI densities are also illustrated. Origin density is positively correlated with early replication domains (*: P < 0.001). (B) Origin number is also positively correlated (*: P < 0.0001) with the early replication timing observed in mouse ES cells (Hiratani et al. 2008).
