Figure 5.
Positive link between HP1 and origin firing/early replication in heterochromatic regions. (A) Density of CGI-like regions in the whole genome and on chromosome 4 in Drosophila. (B) Positive correlation between HP1 binding and early S phase replication timing in Drosophila chromosome 4. Scatter plots between experimental and randomized HP1 data sets and replication timing are shown. The P-value is indicated at the bottom of the panels. (C) Significant association between HP1 binding and origins on the entire Drosophila chromosome 4. (D) A 300-kb region of chromosome 4 showing the relationship between origin firing, HP1 binding and early replication timing.
