Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features

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Figure 3.
Figure 3.

Association of replication origins with CGI in metazoans. Example of replication origins associated with CGI in (A) mouse ES cells and (C) Drosophila cells. The percentage of CGI/replication origin association is also shown. (B) NS signal strength around all CGI in mouse ES cells and (D) CGI-like regions in Drosophila Kc cells. The average size of CGI is shown in scale. (E) Common origins in mouse cells are strongly associated with CGI regions. The proportion of CGI-positive origins in the indicated groups of origins is shown.

This Article

  1. Published in Advance July 12, 2011, doi: 10.1101/gr.121830.111 Genome Res. 21: 1438-1449

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