Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes

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Figure 1.
Figure 1.

Genes with altered RNAPII occupancy upon TA and/or TNF treatment. (A) The number of genes with altered RNAPII occupancy (increased and decreased) in response to TA, TNF, and TA + TNF treatment, as indicated. (B) RNAPII occupancy vs mRNA levels. Scatter plots depicting the Pearson correlation (r) between changes in mRNA levels (y-axis) and in RNAPII occupancy (x-axis) for randomly selected regulated genes. Changes in mRNA and RNAPII occupancy were expressed as fold induction of the indicated treatment over DMSO (in log2 scale).

This Article

  1. Published in Advance July 12, 2011, doi: 10.1101/gr.118042.110 Genome Res. 21: 1404-1416

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