Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs

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Figure 4.
Figure 4.

MicroRNA targeting of paralogous C2H2 genes. (A) Diagram of domain structure of C2H2 zinc-finger genes. (B) The relationship between shared ancestry of KRAB-containing C2H2 genes and shared miRNA sites. The phylogeny inferred from alignment of the KRAB domains is shown, marking at the perimeter those with at least four 8mer sites to the indicated miRNA. (C) Overlap between the predicted targets of the indicated miRNAs.

This Article

  1. Published in Advance June 17, 2011, doi: 10.1101/gr.121210.111 Genome Res. 21: 1395-1403

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