Quantitative evaluation of all hexamers as exonic splicing elements

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Figure 2.
Figure 2.

Examples of the effect of location on the splicing behavior of substituted pre-mRNA molecules. (A) The five locations in exons WT1-5 (top, 51 nt) and Hb2 (bottom, 223 nt). (B) The best correlation of the effect of 6-mer substitutions (LEIsc, log of the enrichment index, scaled) was between the WA and WD locations (R2 = 0.34). (C) The worst correlation was between WD and HA (R2 = 3 × 10−5). The dashed line is the least squares regression fit. The results for all five locations are shown in Supplemental Figure 1.

This Article

  1. Published in Advance June 9, 2011, doi: 10.1101/gr.119628.110 Genome Res. 21: 1360-1374

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