Genome-wide identification of conserved regulatory function in diverged sequences

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Figure 4.
Figure 4.

Putative human and zebrafish enhancer pairs direct similar tissue-specific expression (covert regulatory elements D, E, F, G) (Table 2). (A) Composite overviews of in vivo GFP expression data from 16–20 individual zebrafish embryos per construct. The keys for the marked expression are provided next to each image, followed by the number of fish in the set with that specific expression. (B) One representative GFP live image from each enhancer set is displayed. All zebrafish are 24 hpf oriented with anterior to the left and dorsal to the top. The dotted box demarcates the forebrain. The stacked structures of the notochord are between the dotted lines. Arrows refer to the somites. The solid line box contains the spinal cord. The pronephric duct-consistent expression is marked by the solid line ovals.

This Article

  1. Genome Res. 21: 1139-1149

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