Revealing the genetic structure of a trait by sequencing a population under selection

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Figure 1.
Figure 1.

Overall strategy. A three-step QTL mapping strategy by crossing two phenotypically different strains for many generations to create a large segregating pool of individuals of various fitness, and growing the pool in a restrictive condition that enriches for beneficial alleles that can be detected via sequencing total DNA from the pool.

This Article

  1. Published in Advance March 21, 2011, doi: 10.1101/gr.116731.110 Genome Res. 21: 1131-1138

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