Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants

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Figure 2.
Figure 2.

Haplotype classes (A), their phylogeny (B) for the marker SNP rs405509 showing synthetic association of functional variants rs7412 and rs429358 in the APOE locus. LD coefficients between the SNPs associated with LDL-C (C). Haplotype frequencies were calculated using the PLINK software (Purcell et al. 2007).

This Article

  1. Published in Advance March 25, 2011, doi: 10.1101/gr.115832.110 Genome Res. 21: 1122-1130

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