Figure 6.
Power of nine statistics: FPCA (discretization approach)–based statistics, FPCA (Fourier expansion approach)–based statistic, multivariate PC–based statistic, WSS, VT, collapsing method, generalized T2 statistic, single marker χ2 test, and CMC method (the variants with frequencies ≤ 0.005 were collapsed) as a function of sample sizes for testing association of 22 rare variants, half of which were risk-increasing variants, with the disease under the dominant disease model, assuming baseline penetrance of 0.01.
