Cell type–specific DNA methylation at intragenic CpG islands in the immune system

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Figure 2.
Figure 2.

Cell type–specific methylation occurs at intragenic CGIs. (A) CGIs can be transcription start site (TSS)-associated, intragenic, or intergenic. (B) The distribution of CGIs in the mouse genome (Illingworth et al. 2010). (C) Pairwise comparisons of immune cell types [dendritic cells (DC), Th1 cells, Th2 cells, B cells, and CD4 T-cells] showing the location of methylation changes in each comparison. (D) The percentage of CGIs in each class showing a DNA methylation change in any of the immune cell comparisons. Each CGI was only counted once even if it changed in multiple comparisons.

This Article

  1. Published in Advance May 31, 2011, doi: 10.1101/gr.118703.110 Genome Res. 21: 1074-1086

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