Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis

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Figure 3.
Figure 3.

6C2d-2 is insulin resistant relative to 6C2d-3. (A) Plasma glucose levels were maintained at constant levels throughout the hyperinsulinemic-euglycemic clamp study. (B) Increased glucose infusion rate required to maintain euglycemia in strain 6C2d-3 relative to strain 6C2d-2. (C) Glucose clearance rate (Rd) did not differ between strains 6C2d-2 and 6C2d-3, indicating that (D) endogenous glucose production was increased in strain 6C2d-2. Glucose uptake in (E) muscle, brain and (F) white adipose tissue (WAT) did not differ between the two strains. Data are presented as mean ± SEM. *P < 0.05.

This Article

  1. Published in Advance April 19, 2011, doi: 10.1101/gr.120741.111 Genome Res. 21: 1065-1073

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