Figure 7.
In vivo validation of predicted POU2F1 (Oct1) binding. The prediction algorithm is depicted in A. Significantly enriched words in the top 1% of POU2F1 (Oct1) binding oligonucleotides were added to the predictor with their enrichment score (χ2 statistic). This score calculated over a window of 100 nt was used to the predict POU5F1 ChIP regions in mouse and orthologous regions in human, cow, and dog. (B) High-scoring regions predicting POU2F1 binding were tested by ChIP in mouse. Low-scoring regions predicting background levels of POU2F1 binding were also tested.
