SNP detection and genotyping from low-coverage sequencing data on multiple diploid samples

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Figure 5.
Figure 5.

An illustrative example of a coalescent tree for four samples (eight haplotypes). Given a value at the root, A in this example, and a mutation from A to C in this example, we can infer genotypes for the four samples and, hence, compute the probability of data D conditional on this configuration. We estimate the likelihood of D given a tree t, p(D | t), by summing over all possible root values and mutations in t.

This Article

  1. Genome Res. 21: 952-960

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