Comparative analysis of the primate X-inactivation center region and reconstruction of the ancestral primate XIST locus

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Figure 4.
Figure 4.

Ancestral reconstruction of candidate XIC region. The general phylogeny of the primates is shown along the right side. The approximate size and gene content of the human/chimpanzee/orangutan (H+C+O) ancestor, the human/chimpanzee/orangutan/rhesus (H+C+O+R) ancestor, and the primate ancestor, as determined through multispecies alignment reconstructions, is shown. The size of the primate ancestral XIC region is much smaller than the other ancestral sequences. This is due to repetitive and unique sequence insertions on the haplorrhine ancestral lineage after the divergence of the strepsirrhine primates.

This Article

  1. Genome Res. 21: 850-862

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