Figure 7.
(A) Mouse Ins2-Igf2 fusion object contains a valid CDS, supported by human cDNA and species-specific peptide evidence. (B) Clustal alignment of the translation of the mouse and human fusion transcripts. This human translation would be a target for the NMD pathway due to a frame-shift mutation, caused by the inclusion of an additional exon not present in the mouse transcript. The residues of the Ins2 and Igf2 polypeptides are colored blue and pink; with the known domains within each highlighted in gray.
