Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons

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Figure 2.
Figure 2.

Global DNA methylation assay by LUMA. (Top) HpaII/MspI ratio of the standard samples. (Bottom) HpaII/MspI ratio of the bulk and sorted brain samples. Theoretically, when all CCGG sites are not methylated, the ratio of HpaII/MspI is close to 1, whereas the ratio is expected to be close to 0 when all sites are methylated. To test the accuracy of the methods, we used samples containing various amounts of methylated and unmethylated genomic DNA as standard samples. Values are mean ± SD.

This Article

  1. Published in Advance April 5, 2011, doi: 10.1101/gr.112755.110 Genome Res. 21: 688-696

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