Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Stochasticity in gene expression underlies partial phenotypic penetrance. Summary of data from Raj and colleagues (Raj et al. 2010) explaining partial penetrance of defects in skn-1 mutants. A network controlling intestinal development in C. elegans in wild-type (left) and skn-1 mutants (right). END-1 expression levels must reach a threshold to activate expression of elt-2 and downstream intestinal expression programs.

This Article

  1. Published in Advance February 4, 2011, doi: 10.1101/gr.097378.109 Genome Res. 21: 645-657

Preprint Server



Current Issue

  1. February 2026, 36 (2)
  1. Current Issue
  1. Alert me to new issues of Genome Research