Clustering of MPNST and NF samples using the expression of genes associated with b2mDMRs. (A) The expression level of 1056 genes that contain a hypermethylated b2mDMR in associated CGI shores were used to cluster the MPNST and NF samples. (B) Clustering of the MPNST and NF samples based on the expression of 667 genes associated with the non–CGI-associated promoter b2mDMRs. The two major branches of the dendrogram correspond to a MPNST cluster and NF cluster, respectively. (B) Clustering of the MPNST and NF samples based on the expression of genes associated with hypermethylated non–CGI-associated promoter b2mDMRs. Columns represent individual samples (MPNST, red; NF, blue). (C) Clustering of the MPNST and NF samples based on the expression of genes associated with the hypermethylated CGI-associated promoter b2mDMRs.
