Potential contribution of new molecular mechanisms to mitochondrial dysfunction in AD. The AD candidate gene ECSIT, which is involved in TLR and BMP signaling pathways and also in the assembly of mitochondrial redox complexes, shows additional interactions with several AD causative and candidate genes that are functionally connected. Thus ECSIT can constitute a molecular link among oxidative stress, inflammation, and mitochondrial dysfunction in AD. Literature reported interactions are depicted with black lines, while novel interactions are depicted with red lines. AD seeds are displayed as orange ellipsoids, candidates as red, and literature interactors as green ellipsoids. (ETC) Electronic transport chain.
