Figure 5.
Putative role of PDCD4 as neuronal death regulator in AD. The AD candidate gene PDCD4 undergoes a complex regulation by cytokines, which results in the inhibition of protein translation. This gene is up-regulated in AD human brain tissues and thus the novel associations with AD seeds suggest that PDCD4 could play a role in Aβ neurotoxicity in conjunction with APOE and PSEN2. Literature reported interactions are depicted with black lines, while novel interactions are depicted with red lines. AD seeds are displayed as orange ellipsoids, candidates as red, and literature interactors as green ellipsoids.
