Interactome mapping suggests new mechanistic details underlying Alzheimer's disease

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Figure 1.
Figure 1.

Flow strategy of the approach. Five major steps: (1) identification of potential and causative genes in AD; (2) characterization of the network by a Y2H screening; (3) generation of the AD protein interaction network; (4) experimental and computational assessment of the network coherence; and (5) functional module analysis of the generated AD-PIN.

This Article

  1. Published in Advance December 16, 2010, doi: 10.1101/gr.114280.110 Genome Res. 21: 364-376

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