Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 8.
Figure 8.

Example of a transitional miRNA locus, which exhibits signatures of both RNA degradation as well as Drosha/Dicer-1 processing across its precursor. Each read length has been plotted in a distinct color to emphasize the heterogeneity of cloned species mapping to the 3′ UTR of CG15102. The reads have been ordered on the y-axis with the most abundant individual species at the bottom. It can clearly be seen that a specific set of 21–22 nt reads are specifically made. These map to a typical pri-miRNA hairpin with a lower stem and a miRNA/miRNA* duplex region.

This Article

  1. Genome Res. 21: 203-215

Preprint Server