Figure 5.
SVM-predicted regions are hypersensitive to DNase I in the relevant context. To independently confirm our predictions with DNase I measurements in the embryonic mouse brain, we plot the distributions of the average intensity of DNase I hypersensitivity of different forebrain SVM scoring regions. (A) DNase I hypersensitivity measured in E14.5 wholebrain. (B) DNase I hypersensitivity measured in an adult 8-wk kidney, as a negative control. We observe significant enrichments only in high-scoring SVM-predicted regions in the brain.
