Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred

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Figure 3.
Figure 3.

Expression pattern of WDR81 in brain. (A) Expression in human brain with highest levels in cerebellum and corpus callosum. (B) In situ hybridization of mouse embryonic brain revealing increased expression of Wdr81 in purkinje cells and molecular layer of cerebellum. (C) No hybridization was observed with the sense probe. (ML) Molecular layer, (GL) granular layer.

This Article

  1. Published in Advance September 1, 2011, doi: 10.1101/gr.126110.111 Genome Res. 21: 1995-2003

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