Genome-scale phylogenetic function annotation of large and diverse protein families

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Figure 5.
Figure 5.

A comparison of BLAST and SIFTER for the Nudix family of proteins. SIFTER consistently dominates BLAST annotations under this criterion. The SIFTER-C and the BLAST-C lines are the evaluation of SIFTER and BLAST using the generalized Nudix hydrolase terms as experimental annotations. It is interesting that, at >99% specificity, both BLAST and SIFTER performed as well or better on the original data sets than the generalized data sets. Note that the x-axis is on a log scale.

This Article

  1. Published in Advance July 22, 2011, doi: 10.1101/gr.104687.109 Genome Res. 21: 1969-1980

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