Immune-related families. (A) Alignment of human sequences of members of three immune-related families. UTRP40 includes some additional members not found in the GW families. The families are enriched for macrophage-related genes and GO immunity term association (red). Substitutions are color-coded as in Figure 2. The stems are generally more conserved (black bars) than the loops (predictions without gene symbols are labeled by EvoFold id). (B) Family members (green) overlap with known stabilization/destabilization elements (red). All three genes also have known AREs (blue) (including the ARE-like stability and efficiency element, SEE) (Hel et al. 1998).
