Masako Suzuki; Mayumi Oda; María-Paz Ramos; Marién Pascual; Kevin Lau; Edyta Stasiek; Frederick Agyiri; Reid F. Thompson; Jacob L. Glass; Qiang Jing; Richard Sandstrom; Melissa J. Fazzari; R. Scott Hansen; John A. Stamatoyannopoulos; Andrew S. McLellan; John M. Greally

Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome

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Figure 3.

Broad correlation exists between DNA hypermethylation and actively transcribed gene regions. Extending the analysis of Supplemental Figure 3 to a 100-kb sliding window representation continues to show the relationship between increased gene expression and hypermethylation of DNA. A two-dimensional histogram of the averaged HpaII/MspI log₂ ratio in 100-kb windows and averaged signal intensities of the genes are represented by filled contour plots.