Figure 2.
DNA hypermethylation correlates with early DNA replication timing. Filled contour plots were drawn with two-dimensional histograms. Cytosine methylation data and replication timing data are averaged in 100-kb sliding windows. The cumulative numbers of observations are shown as color-coded levels to generate the contours. Early replicated regions are more methylated in both the fibroblast and lymphoblastoid cell types.
