Figure 4.
Changes in orthologous zinc fingers and duplicate zinc fingers compared with diversity among all fingers. (Top) The averaged relative rates of divergence in 280 orthologous ZF domains from 22 randomly chosen KZNF genes (see Methods). (Middle) The diversity among all ZF domains from human KZNF genes as a logo plot (http://weblogo.berkeley.edu). (Bottom) The number of conserved changes observed among the 390 testable zinc fingers in all 34 duplicate gene pairs analyzed. Circles labeled P indicate residues that make major phosphate contacts and squares labeled N indicate residues that make the major nucleotide contacts.
