Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 6.
Figure 6.

Hyperglycemia confers distinguishable gene-activating histone hyperacetylation and DNA methylation changes in the human vascular cell. (A,B) Red arrows represent regions in the genome with changes in values >1.6-fold mediated by hyperglycemia. (A) Decreased CpG-seq counts mediated by hyperglycemia. (B) Increased acetylation ChIP-seq counts conferred by hyperglycemia. Genes were associated with increased CpG methylation (green), decreased methylation (purple), increased acetylation (red), and decreased acetylation (blue). (C) Integration of H3K9/K14 hyperacetylation and CpG methylation associated with gene expression changes.

This Article

  1. Published in Advance September 2, 2011, doi: 10.1101/gr.116095.110 Genome Res. 21: 1601-1615

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research