Figure 6.
Summarizing model. Schematic representation showing the different steps from the OPA1 gene to the generation of NT-OPA1-exon4b peptide and its interaction with the mitochondrial nucleoid. (E1 to E29) OPA1 exon 1 to exon 29; (MTS) mitochondrial targeting sequence; (GED) GTPase effector domain; (TM) transmembrane domain; (MPP) mitochondrial processing peptidase; (YME1L) inner membrane protease cleaving OPA1-exon4b; (IMS) inner membrane space; (IMM) inner mitochondrial membrane. (White spot) TFAM protein; (black spot) POLG; (gray spot) an unknown protein linking NT-OPA1-exon4b peptide to the mtDNA.
