Figure 4.
Four promoters that exhibit tumor-specific methylation. Sequencing reads from all patients for each type of tissue are grouped together in panels; breast tumors, adjacent normal breast tissues, colon tumors, and adjacent normal colon tissues. The sequencing reads are aligned as rows in each panel and are grouped by patient. Each base in the read is color-coded to indicate the sequence: (yellow) a methylated cytosine; (blue) all other bases. (A,B) ICAM5 and LAMA1 promoters exhibit colon and breast tumor-specific methylation. (C,D) KCNQ5 and CLSTN2 promoters exhibit colon tumor-specific methylation.
