Gene amplification as double minutes or homogeneously staining regions in solid tumors: Origin and structure

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

(Lower part of each section) Schematic representation of the structure of the amplicon. Different blocks composing the amplicons are represented by arrows of different color. (Upper parts) Arrangement of the amplified blocks in the reference sequence (hg18). (Gray line segments) Nonamplified regions; (vertical figures) boundaries of the breaks, at single-base resolution if sequenced (Supplemental Fig. 4), or as a small interval (maximum interval size: 2.5 kb); (?) uncloned fusion regions. In STA-NB-10 the deleted regions (del) internal to the amplified region are indicated. The lengths of the arrows are only approximately proportional the DNA segment length.

This Article

  1. Genome Res. 20: 1198-1206

Preprint Server