Gene amplification as double minutes or homogeneously staining regions in solid tumors: Origin and structure

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 1.
Figure 1.

Partial metaphases showing cohybridization FISH experiments using WCP specific for chromosome 2 (green) and RP11-480N14 (chr2:15,999,497–16,004,580), containing the MYCN gene (red). GLC8, STA-NB-4, STA-NB-8, STA-NB-10/dmin, and STA-NB-13 showed MYCN amplification in form of dmin (example provided at right). The remaining cell lines displayed hsr amplification in a single location (SK-N-BE, STA-NB-10/hsr) or in multiple locations (GLC14, STA-NB-3, STA-NB-15). Note the absence of the RP11-480N14 signal on one of the two chromosomes 2 in STA-NB-10 clones (arrows).

This Article

  1. Published in Advance July 14, 2010, doi: 10.1101/gr.106252.110 Genome Res. 20: 1198-1206

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research