Figure 2.
SNP rs6983267 mediates allelic-specific enhancer activity in mouse prostates. Three independent transgenic founders harboring reporter plasmids driven by either the G (risk) allele (A) or T (non-risk) allele (B) are shown at P8. (Dashed lines) Outlines of prostates; (CG) coagulating glands. The prostate cancer risk allele leads to consistently stronger beta-galactosidase expression in prostates and coagulating glands than the non-risk allele in vivo. (C) MYC in situ hybridization at P8 correlates with the reporter expression pattern driven by the rs6983267-containing enhancer.
