Susceptibility to chronic pain following nerve injury is genetically affected by CACNG2

Fine mapping of Pain1 using RPT and RIST. (A) The RPT experiment. The region of chromosome 15 containing Pain1 and the genotype of 17 SNPs for the eight recombinant progenitor males (and two additional SNPs for progenitor #6) are shown. Here, and in B, “Autotomy %” is the percentage of animals with an autotomy score >1; n = the number of female mice phenotyped, and MA is the mean autotomy score. (B) The RIST experiment. For each of the four BC populations—(B₁ ) two BXA7 BCs; (B₂ ) two BXA8 BCs—a comparison of A/A (homozygous A/J) versus A/B (heterozygous A/J-C57BL/6J) at the relevant SNP is shown. (C) RIST and RPT map integration.