Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver

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Figure 2.
Figure 2.

Bimodal and monomodal transcription factor occupied loci have a similar genomic distribution. (A) Distributions of distance to the closest transcriptional start site (dTSS) for transcription factor occupied loci within 50 kb of a RefSeq gene TSS. (B) Fractions of bimodal, monomodal, or low H3K4me1 sites in transcriptionally active, inactive, or non-genic regions. (C) Proportion of bimodal, monomodal, or low H3K4me1 sites associated with an expressed (tag count >5), non-expressed (H3K4me3 marks at the promoter, tag count <5), or silenced (no H3K4me3 at the promoter, tag count <5) genes.

This Article

  1. Genome Res. 20: 1037-1051

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