Data sets collected and analysis scheme of the current study. The three data sets (P450 activity traits, gene expression, SNP genotyping) are shown in rectangles. The data analyses conducted are labeled above, below, or between the data sets. These include (1) activity–activity correlation among enzyme activity measures, (2) gene–gene correlation among gene expression levels, (3) activity–gene correlation between genes and activity levels, (4) coexpression network construction based on expression levels, (5) activity–module correlation between activity measurements and coexpression modules, (6) SNP–gene association (expression SNP or eSNP) between genotype and gene expression, (7) SNP–activity association (activity SNP or aSNP) between genotype and enzyme activity, and (8) Bayesian network construction based on both expression and genotype data.
