Functional consequences of ARE and URM motifs after miRNA transfections in HeLa cells, (A) Gene set enrichment analysis (GSEA) showing that genes with ARE motif overrepresentation are enriched for inflammatory pathways (INFLAMPATHWAY). (B) Genes up-regulated after miRNA transfections were enriched for cytokine-cytokine receptor interaction (HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION). (C) Genes with overrepresentation of the URM1 motif were enriched for a manually curated gene set (CHESLER_HIGHEST_FOLD_RANGE_GENES) of neurologically relevant transcripts with high fold range between mouse inbred strains. (D) Genes down-regulated after miRNA transfections were also enriched for this gene set.
